Informed Consent Document

Purpose of the Study

You are invited to participate in a research study conducted by Renue By Science. The purpose of this study is to evaluate the effects of nighttime NAD+ Complete supplementation on sleep quality, as measured by Oura Ring sleep data and participant-reported daily notes.

This study is designed to collect real-world data from everyday users of the NAD+ Complete supplement, with the goal of understanding whether bedtime administration impacts sleep architecture, deep sleep duration, and subjective daytime energy and mental clarity.

What Participation Involves

If you agree to participate, you will be asked to:

• Complete a 14-day study period consisting of a 7-day baseline phase (no supplement) followed by a 7-day supplementation phase (NAD+ Complete at bedtime).
• Wear an Oura Ring to bed every night for the full 14 days and export your sleep data at the end of each phase.
• Complete brief daily notes each morning, logging factors such as caffeine intake, exercise, meal timing, energy levels, and mental clarity.
• Take NAD+ Complete as directed during Phase 2 (2 capsules at bedtime, approximately 30 minutes before sleep).
• Upload your Oura Ring data and daily notes through your participant dashboard.

The total time commitment is estimated at 5-10 minutes per day for daily notes, plus the time needed for two Oura data exports (approximately 5 minutes each).

Risks and Discomforts

The risks associated with this study are considered minimal. NAD+ Complete is a dietary supplement, not a pharmaceutical drug. It contains NMN, NR, and NAD+ — naturally occurring molecules involved in cellular energy metabolism.

• Known potential side effects are rare and may include mild digestive discomfort, vivid dreams, or slight flushing. These are typically transient and resolve on their own.
• Unknown risks: While NAD+ precursors have been studied extensively, long-term effects of specific formulations are still being researched.
• Data collection risks: There is a minimal risk of data breach. We mitigate this through encryption and access controls (see Confidentiality section below).

If you experience any adverse effects, you may report them immediately through the Report Adverse Event feature on your participant dashboard, or by emailing research@renuebyscience.com.

Benefits

Potential benefits of participation include:

• Free product: You will receive a full supply of NAD+ Complete for the supplementation phase at no cost.
• Biological age report: Upon study completion, you will receive a personalized report analyzing your sleep data, including comparisons between your baseline and supplementation periods.
• Contributing to science: Your participation helps advance our understanding of NAD+ supplementation and sleep quality, contributing to research that may benefit others.

These benefits are not guaranteed outcomes. Individual results may vary.

Confidentiality

Your privacy is important to us. We take the following steps to protect your data:

• Anonymization: Your data will be assigned a unique participant ID. Published results will never include your name, email, or any personally identifiable information.
• Secure storage: All data is stored on encrypted cloud infrastructure with access limited to the Renue Research team. Our infrastructure providers are reputable, security-audited services that comply with industry-standard data protection practices.
• No data sales: Your personal data and sleep data will never be sold or shared with third parties for marketing purposes.
• Limited access: Only authorized members of the research team will have access to your individual data. Aggregate, anonymized data may be used in publications or presentations.
• Shipping fulfilment: If your study involves shipped materials (such as supplements), your name, shipping address, and phone number are shared with our fulfilment partners (Shopify and ShipStation), our warehouse team, and the carrier (USPS) for the sole purpose of delivering the product. They do not receive any research data, only the information required to ship the package.

Voluntary Participation

Your participation in this study is entirely voluntary. You may:

• Decline to participate without any penalty or loss of benefits.
• Withdraw from the study at any time, for any reason, by clicking Withdraw from Study on your Profile page or emailing the research team.
• Request deletion of your data at any time, even after the study concludes.

Withdrawing from the study will not affect your relationship with Renue By Science in any way. You will not be penalized for withdrawal, and you may keep any remaining supplement.

Contact Information

If you have questions about this study, your rights as a participant, or if you experience any issues during the study, please contact: