Research Pre-Screening

Step 1 of 3 -- Pre-Screen

Complete this short form to apply for a Renue research study. Our team will review your responses and contact you within 5 business days.

Pre-Screening Information and Acknowledgment

Study Title: Real-World Evaluation of Dietary Supplements and Lifestyle Interventions Using Longitudinal Self-Tracking and Wearable Data - Sub-Study: Nighttime NAD+ Complete and Deep Sleep

Principal Investigator: Rebecca Crews, Ph.D.

Conducted by: Renue By Science

Before you begin

Thank you for your interest in this research study. Before we can tell you whether you qualify to participate, we need to ask you some questions about your age, health, medications, and supplement use. This short page explains why we collect that information, what we do with it, and your rights. Please read it before starting the screening survey.

This is not the full consent form. If you qualify and choose to continue, you will be given a separate informed consent form that describes the full study in detail. You will only be enrolled in the study after you sign that form.

Why we are asking these questions

This study looks at how dietary supplements and lifestyle changes affect real-world health and wellness. To protect your safety and make sure the study is a good fit for you, we need to check a few things first, including your age, general health, current medications, and supplement use. The only reason we collect this information right now is to decide whether you are eligible to take part in the study.

What we will ask about

Your age and ability to complete online surveys in English
Whether you are pregnant or breastfeeding
Whether you are currently in another research study
Your general health history, including certain medical conditions
Medications and supplements you currently take
Any past reactions you have had to supplements
Your Oura Ring use, NAD+ precursor history, and ability to participate in the sub-study

You do not have to answer any question you are not comfortable with. However, if you skip questions needed to determine eligibility, we may not be able to enroll you.

How we protect your information

Your answers are linked to a Study ID number, not your name, within our research database.
Contact information you provide (such as your email) is stored separately from your health answers.
Only authorized study staff can view your screening responses.
Your screening answers will not be shared with Renue By Science marketing, sales, or customer service teams.
Your screening answers will not affect your Renue By Science account, pricing, product access, or customer relationship in any way.
Data are stored on secure, encrypted systems. More detail on data security is provided in the full consent form if you qualify and choose to continue.

What happens to your answers

If you qualify and choose to enroll: Your screening answers become part of your study record and are handled under the protections described in the full consent form.

If you do not qualify, or choose not to continue: Your screening answers are kept in de-identified form only (with your name and contact information removed) so we can report how many people were screened for the study. They are not used for any other research, marketing, or commercial purpose.

You can ask us to delete your screening information at any time by contacting the research team at the address below, as long as it has not already been de-identified.

Your rights

Completing the screening survey is completely voluntary.
You can stop at any time, for any reason, without giving a reason.
Your decision will not affect your Renue By Science account, orders, pricing, or relationship with the company in any way.
If you have questions before starting, you can contact the research team at research@renuebyscience.com.
If you have questions about your rights as a research participant, you can contact Beyond Bound IRB at +1 (646) 217-0403 or info@beyondbound.org.

Acknowledgment

By selecting "I understand and wish to continue" below, you confirm that:

You have read the information above.
You understand that this screening is being done to determine your eligibility for a research study.
You understand that this is not full informed consent, and that full consent will be requested separately if you qualify and choose to continue.
You voluntarily agree to answer the screening questions.

I understand and wish to continue. *

Full name *

Email address * We will contact you at this address if you are selected

Section 1 - Basic Eligibility

Are you 18 years of age or older? *

Do you reside in the United States? *

Are you comfortable completing short online surveys on a phone, tablet, or computer on a regular basis? *

Can you read and understand study materials written in English well enough to make an informed decision about participation? *

Are you willing to maintain your current diet, sleep schedule, and activity level for the duration of the study (approximately 2-3 weeks)? *

Section 2 - Pregnancy

Are you currently pregnant, trying to conceive, or breastfeeding? *

Section 3 - Current Study Enrollment

Are you currently enrolled in a clinical trial or research study involving an investigational drug or compound? *

Section 4 - Medical History

In the past 5 years, have you been diagnosed with cancer? *

Are you currently taking antibiotics, or have you taken antibiotics within the past 14 days? *

No Yes, I am currently taking antibiotics Yes, I took antibiotics within the past 14 days

Have you had surgery in the past 4 weeks, or do you have surgery planned within the next 4 weeks? *

Do you have any of the following conditions? * Select all that apply.

Liver disease, cirrhosis, or hepatitis Chronic kidney disease or dialysis dependence Active autoimmune disease currently under treatment Cardiac arrhythmia, or a heart attack or stroke within the past 6 months Unstable chronic disease (recent hospitalization, medication changes in the last 3 months, uncontrolled hypertension/diabetes) Active psychiatric instability (within the past 6 months: hospitalization, suicide attempt, or a significant change in psychiatric medication) None of the above

Section 5 - Lifestyle

Do you consume more than 14 alcoholic drinks per week? *

Do you currently use tobacco or nicotine products (cigarettes, vaping, chewing tobacco, etc.)? *

Do you work night shifts or have a highly irregular sleep schedule? *

Section 6 - Current Medications

Do you currently take any of the following medications? * Select all that apply.

Blood thinners or anti-clotting medications (warfarin, clopidogrel, apixaban) Thyroid medications (levothyroxine, methimazole) Immunosuppressants or biologics (cyclosporine, tacrolimus, methotrexate) MAOIs or lithium Seizure, heart, or HIV medications (digoxin, phenytoin, carbamazepine, antiretrovirals) Hormonal therapies (estrogen, progesterone, or hormonal contraceptives) None of the above

Please list all current medications (prescription and over-the-counter) with dose and frequency. Optional.

Section 7.1 - Oura Ring Use

Do you currently wear an Oura Ring (Generation 3 or Generation 4) with an active Oura Membership? *

Are you willing to connect your Oura account to the study dashboard so the study team can access your sleep data for the study? *

Yes No Unsure - would like more information

Are you willing to wear your Oura Ring every night for two 7-night tracking periods (~14 nights total) and keep your Oura account connected so sleep data is shared with the study team? *

Section 7.2 - NAD+ Precursor Use

Do you currently take an NAD+ precursor supplement, and when? * NAD+ precursors include NMN, NR, NAD+, NA, NAM, NAD+ Complete, or any combination product.

No, I do not take an NAD+ precursor supplement Yes, regularly in the morning (before 11:00 AM) with consistent daily timing Yes, regularly in the afternoon or evening (after 11:00 AM) Yes, but the timing varies day to day

Section 7.4 - Sleep Aids and Disorders

Do you have a diagnosed sleep disorder requiring active treatment (e.g., obstructive sleep apnea using CPAP, narcolepsy, restless legs requiring medication)? *

Have you started, stopped, or changed the dose of any sleep medication (prescription or over-the-counter) within the past 14 days? *

Do you currently use sleep aids regularly (melatonin, prescription sleep medications, or sleep supplements)? * Regular use is not exclusionary as long as your dose is stable.

Are you currently sick, recovering from an illness, or experiencing symptoms that could affect your sleep or recovery? *

Section 7.5 - Travel and Routine Stability

Have you traveled across 2 or more time zones within the past 2 weeks? *

Do you plan to travel across 2 or more time zones during the next 3 weeks? *

Do you anticipate any major routine disruption during the study window (surgery, major life event, exam period, etc.)? *

Do you plan to start any new supplement, medication, diet, exercise routine, or other major lifestyle change within the next three weeks? *

Section 7.6 - Ingredient Allergies

Do you have any known allergy or sensitivity to any of the listed ingredients, or to soy or sunflower lecithin? * NAD+ Complete contains: Liposomal NMN, Liposomal NAD+, Liposomal NR, and Liposomal Trigonelline, plus standard liposomal carrier components (phospholipids derived from soy or sunflower).

No Yes Unsure

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